By H. Ines. Concordia University, Irvine California.
Modulation of Membrane Trafficking-Genipin/Mrp2 Genipin is an intestinal bacterial metabolite of geniposide cheap kamagra 100mg amex erectile dysfunction groups in mi, a major ingredient of a herbal medicine purchase genuine kamagra line impotence 101, Inchin-ko-to kamagra 50mg low cost erectile dysfunction treatment bangkok, which have potent choleretic effects, and it rapidly stimulates redistribution of Mrp2 to the canalicular membrane in rats (365). Infusion of genipin for 30 minutes significantly increased the biliary excretion of glutathione in normal rats. Accordingly, genipin treatment increases an insertion of Mrp2 to the canalicular membrane and/or decreases internalization by known mechanism. The same strategy will be also effective in predicting induction of drug transporters. Most transporters involved in the drug disposition are characterized by broad substrate specificities and accept structurally unrelated compounds. Using gene knockout/deficient animals and selective inhibitors, scientists have investigated the roles of transporters in drug disposi- tion. Drug-drug interactions involving transporters include direct inhibition or indirect modulation, and thereby, affect the pharmacokinetics of the substrate drugs. For direct inhibition, using unbound concentration of inhibitors and inhibition constant of the target transporter, one can quantitatively evaluate the degree of inhibition of the target transporter. This rough estimation will be helpful for prescreening of drug-drug interaction and evaluation of in vivo rel- evance of such inhibition in the drug-drug interactions. This chapter focused on the molecular characteristics of drug transporters and drug-drug interaction involving these drug transporters. Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data. Quantative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism together with binding and transport. Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats. Function of uptake transporters for taurocholate and estradiol 17b - D-glucuronide in cryopreserved human hepatocytes. Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes. Formation of extensive canalicular net- works by rat hepatocytes cultured in collagen-sandwich configuration. Correlation of biliary excretion in sandwich- cultured rat hepatocytes and in vivo in rats. Use of Ca modulation to evaluate biliary excretion in sandwich- cultured rat hepatocytes. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: vesicle hetero- geneity, coexistence of transport system. Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to serosal surface. Influence of shunt on transmural sodium transport and electrical potential differences. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Molecular and functional character- ization of intestinal Na(þ)-dependent neutral amino acid transporter B0. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). Expression, localization, and functional character- istics of breast cancer resistance protein in Caco-2 cells. Drug absorption limited by P-glycoprotein- mediated secretory drug transport in human intestinal epithelial Caco-2 cell layer. Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta. Multidrug resistance-related trans- port proteins in isolated human brain microvessels and in cells cultured from these isolates. Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. Contribution of sodium taurocholate co- transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. Contribution of organic anion trans- porters to the renal uptake of anionic compounds and nucleoside derivatives in rat. Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. The heteromeric organic solute trans- porter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. Immunologic distribution of an organic anion transport protein in rat liver and kidney. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kid- ney. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Molecular characterization and tissue distri- bution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2.
Olive oil is the best of lubricants buy generic kamagra on-line erectile dysfunction ring, and the carbolized oil is used for chafing and upon hands and instruments in surgery generic kamagra 100mg amex erectile dysfunction viagra not working, and in vaginal examinations purchase cheap kamagra on-line impotence statistics, and in introducing bougies or catheters. If a stream of warm oil be forced into the urethra in spasmodic stricture just in advance of the catheter, the dilation may be made satisfactorily, and the catheter may be introduced when that act was previously impossible. Olive oil is exceedingly valuable in the treatment of sprained, bruised or contused parts, applied warm on absorbent cotton and kept hot. It acts as nutrition to the part, diffuses the heat and is markedly soothing in its influence. Olive oil is used to protect the mucous surfaces of the esophagus and Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 309 stomach when poisoning has occurred from the caustic alkalies. It also forms a neutral innocuous soap with the alkali and can subsequently be removed. In some cases a fatal loss of time occurs from depending upon this, when magnesia or lime water or soda or a soap solution should have been introduced to neutralize the acid. The substance is very mucilaginous, and an infusion will quickly become jelly-like. Weakness of the osseous structure, rickets, diarrhea and dysentery from local irritation in poorly nourished patients, Therapy—With some physicians this agent is very popular in the treatment of the above disorders. It is also useful in weak back, especially in those cases where, with weakness of the muscular structure of the back, there are symptoms of incipient disease of the spinal vertebrae. In the treatment of diarrhea and dysentery, whether acute or accompanying protracted fevers, the agent is said to be very beneficial, especially if accompanied with great weakness. It has been given in various form of female weakness, particularly where there was severe leucorrhea. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 310 The Wm. Specific Symptomatology—It is indicated where there is dropsy, especially in aged people, or general dropsical effusion, accompanied with loss of vital tone. It is not only used in anasarca and ascites, but also in pleuritic effusion, hydropericardium and hydrocele. It improves the general condition on which the dropsy depends, increasing the action of the heart and arterial tension. Smith reports several cases in which the general dropsy was relieved in a very short time. The remedy improved the general nutrition in each of the cases, overcame difficult breathing and increased the power of the heart. In the dropsy of the aged, that follows prostrating disease, oxydendron is indicated. It is indicated where there is deficient renal action, especially if there is some painful urination, and in the urinary irregularity of old people. It is not easy to define that class of cases of dropsy in which it is specific as in some it works beautifully and in others it is ineffective. Graves says that where there is general edema from dropsy of the heart, liver or kidneys—general dropsy—he has had good results. He gives from twenty to thirty drops of the specific medicine every four hours and could give even larger doses. Where there is dropsy of the serous cavities, he thinks it is not the best remedy. Manley gives sour-wood with other remedies in the dropsy of diabetes, and believes that it improves the general condition of the patient. One of our doctors said his grandfather, an old botanic physician, gathered the leaves and boiled them in water for three hours. He would then strain the decoction and reduce the fluid until it was entirely evaporated. He would roll it up in form of pills and give one of them three or four times a day, improving his cases of dropsy very generally. This remedy is considered valuable in the treatment of prostatic disease, chronic enlargement of the prostate, with irritation at the neck of the bladder, urinary irritation from other causes, especially the urinary difficulties of the aged. It is a diuretic, more or less active in proportion to Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 311 the size of the dose. It promotes the absorption and elimination of dropsical effusions in a characteristic manner, especially those of the abdominal cavity. Given to patients suffering from protracted fever, it will make a cooling and pleasant drink, which promotes the elimination of all of the excretions and restores secretion. Felter and Lloyd state that when a frequent desire to urinate is accompanied with a burning pain at the urethral outlet, the urine passed in drops and mixed with a little blood, it is an especially valuable remedy. Therapy—This agent is an important article of commerce in China, being a general domestic remedy and highly prized. It is a mild sedative and tonic to the nerve centers, improving their tone, if persisted in, and increasing the capillary circulation of the brain. It is given in cerebral anemia, and if combined with other tonics is capable of doing some good. It is also prescribed in the failure of digestion incident to nervous prostration and general nerve irritation. Opium is the concrete milky exudation obtained by incising the unripe capsules of the white poppy of Asia Minor. Dose, five Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 312 to twenty minims. A white or colorless crystalline body in shining prismatic crystals; soluble in thirty-six parts of hot alcohol, and in alkalies; almost insoluble in water. A yellowish-white crystalline body, or an amorphous powder, bitter, inodorous except a slight odor of the acetic acid; soluble in two and one- half parts of water. In white feathery, silky crystals, without odor; of an intensely bitter taste; soluble in twenty-one parts of water and in seven hundred parts of alcohol. Muriate of Morphine occurs in white needle-shaped, feathery, lustrous crystals; bitter and odorless; soluble in twenty-four parts of water and in sixty-two parts of alcohol. This is the product of the action of hydrochloric acid on a modified form Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 313 of the alkaloid morphine. It occurs as white or grayish white crystals, without odor, bitter, turning slightly green upon exposure to the air; soluble in forty-five parts of either water or of alcohol. The dose for this purpose is from one-twentieth to one-sixteenth of a grain, although one-eighth of a grain may be given. It may be given to eject bodies from the esophagus to evacuate the stomach after the injection of poisons, and in extreme asthmatic or catarrhal attacks. A field of action has developed for this remedy, outside of its influence as an emetic, which is important.
Capsule (unbuffered enteric‐coated): 125 mg; 200 mg; 250 mg; didanosine (ddI) 400 mg buy cheap kamagra 100 mg erectile dysfunction herbs a natural treatment for ed. Ritonavir is recommended for use in combination as a pharmacological booster buy cheap kamagra line impotence trials, and not as an antiretroviral in its own right order kamagra on line amex erectile dysfunction toys. Tablet: 200 mg + 300 mg (disoproxil fumarate equivalent to 245 mg tenofovir disoproxil). Tablet (dispersible): lamivudine + nevirapine + stavudine 30 mg + 50 mg + 6 mg [c]; 60 mg + 100 mg + 12 mg [c]. Tablet: 30 mg + 50 mg + 60 mg [c]; lamivudine + nevirapine + zidovudine 150 mg + 200 mg + 300 mg. Injection for intravenous administration: 800 mg and 1 g in 10‐ml phosphate buffer solution. Complementary List Vial or prefilled syringe: pegylated interferon alpha (2a or 180 micrograms (peginterferon alfa‐2a); 2b)* 80 micrograms; 100 micrograms (peginterferon alfa‐2b). Injection: ampoules, containing 60 mg anhydrous artesunic acid with a separate ampoule of 5% sodium bicarbonate solution. Rectal dosage form: 50 mg [c]; 200 mg capsules (for pre‐ artesunate* referral treatment of severe malaria only; patients should be taken to an appropriate health facility for follow‐up care) [c]. Injection: 80 mg + 16 mg/ml in 5‐ml ampoule; sulfamethoxazole + trimethoprim 80 mg + 16 mg/ml in 10‐ml ampoule. Medicines for the treatment of 2nd stage African trypanosomiasis Injection: 200 mg (hydrochloride)/ml in 100‐ml bottle. In view of this, no changes were made to this section during the 19th Expert Committee. Solid oral dosage form: 200 mg; 250 mg; 300 mg; 400 mg; 500 mg; hydroxycarbamide 1 g. Injection: 40 mg/ml (as sodium succinate) in 1‐ml single dose vial and methylprednisolone [c] 5‐ml multidose vials; 80 mg/ml (as sodium succinate) in 1‐ml single dose vial. Tablet equivalent to 60 mg iron + 400 micrograms folic acid ferrous salt + folic acid (nutritional supplement for use during pregnancy). Injection: 1 mg (as acetate, hydrochloride or as sulfate) in 1‐ml hydroxocobalamin ampoule. Injection: 100 micrograms/ml (as acid tartrate or epinephrine (adrenaline) hydrochloride) in 10‐ml ampoule. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines. Its use in the treatment of essential hypertension is not recommended in view of the availability of more evidence of efficacy and safety of other medicines. However, as the stability of this latter formulation is very poor under tropical conditions, it is only recommended when manufactured for immediate use. Complementary List [c] Lugolʹs solution Oral liquid: about 130 mg total iodine/ml. This site will be updated as new position papers are published and contains the most recent information and recommendations. Complementary List epinephrine (adrenaline) Solution (eye drops): 2% (as hydrochloride). Complementary List mifepristone* – misoprostol* Where permitted under national Tablet 200 mg – tablet 200 micrograms. Complementary List Concentrate for oral liquid: 5 mg/ml; 10 mg/ml (hydrochloride). Inhalation (aerosol): 100 micrograms per dose; budesonide [c] 200 micrograms per dose. Injection: 1 mg (as hydrochloride or hydrogen tartrate) in epinephrine (adrenaline) 1‐ml ampoule. It implies that there is no difference in clinical efficacy or safety between the available dosage forms, and countries should therefore choose the form(s) to be listed Solid oral dosage form depending on quality and availability. The term ʹsolid oral dosage formʹ is never intended to allow any type of modified‐release tablet. Refers to: uncoated or coated (film‐coated or sugar‐coated) tablets that are intended to be swallowed whole; unscored and scored ;* tablets that are intended to be chewed before being swallowed; Tablets tablets that are intended to be dispersed or dissolved in water or another suitable liquid before being swallowed; tablets that are intended to be crushed before being swallowed. The term ʹtabletʹ without qualification is never intended to allow any type of modified‐release tablet. Refers to a specific type of tablet: chewable ‐ tablets that are intended to be chewed before being swallowed; dispersible ‐ tablets that are intended to be dispersed in water or another suitable liquid before being swallowed; soluble ‐ tablets that are intended to be dissolved in water or another suitable liquid before being swallowed; crushable ‐ tablets that are intended to be crushed before being swallowed; scored ‐ tablets bearing a break mark or marks where sub‐division is Tablets (qualified) intended in order to provide doses of less than one tablet; sublingual ‐ tablets that are intended to be placed beneath the tongue. The term ʹtabletʹ is always qualified with an additional term (in parentheses) in entries where one of the following types of tablet is intended: gastro‐resistant (such tablets may sometimes be described as enteric‐coated or as delayed‐release), prolonged‐release or another modified‐release form. Capsules The term ʹcapsuleʹ without qualification is never intended to allow any type of modified‐release capsule. The term ʹcapsuleʹ with qualification refers to gastro‐resistant (such capsules may sometimes be described as enteric‐coated or as delayed‐ Capsules (qualified) release), prolonged‐release or another modified‐release form. Preparations that are issued to patient as granules to be swallowed without further preparation, to be chewed, or to be taken in or with water or another suitable liquid. Granules The term ʹgranulesʹ without further qualification is never intended to allow any type of modified‐release granules. Preparations that are issued to patient as powder (usually as single‐ Oral powder dose) to be taken in or with water or another suitable liquid. Oral liquids presented as powders or granules may offer benefits in the Oral liquid form of better stability and lower transport costs. It is preferable that oral liquids do not contain sugar and that solutions for children do not contain alcohol. Injection (qualified) Route of administration is indicated in parentheses where relevant. Intravenous infusion Refers to solutions and emulsions including those constituted from powders or concentrated solutions. Other dosage forms Mode of Term to be used administration To the eye Eye drops, eye ointments. When half a tablet is required, use a cutter or a tablet cutter to cut the tablet into two equal parts. Dosage and duration – Treatment of recurrent or extensive oral and oesophageal herpes in immunocompromised patients, treatment of herpetic kerato-uveitis Child under 2 years: 200 mg 5 times per day for 7 days Child over 2 years and adult: 400 mg 5 times per day for 7 days – Treatment of genital herpes Child over 2 years and adult: 400 mg 3 times per day for 7 days; in immunocompromised patients, continue treatment until clinical resolution – Secondary prophylaxis of herpes in patients with frequent and/or severe recurrences Child under 2 years: 200 mg 2 times per day Child over 2 years and adult: 400 mg 2 times per day – Treatment of severe forms of zoster Adult: 800 mg 5 times per day for 7 days Contra-indications, adverse effects, precautions – Do not administer to patients with hypersensitivity to aciclovir. Aciclovir administration does not reduce the likelihood of developing zoster- associated pain but reduces the overall duration of this pain. When necessary: half a tablet 3 times/day – Adult: 3 to 6 tablets/day after meals or 1 tablet during painful attacks Duration – According to clinical response Contra-indications, adverse effects, precautions – May cause: constipation (except when tablets contain magnesium salts or magnesium hydroxide). Increase to 50 mg once daily the following week, then 75 mg once daily at bedtime as of the third week (max. Duration – Neuropathic pain: several months (3 to 6) after pain relief is obtained, then attempt to stop treatment. Contra-indications, adverse effects, precautions – Do not administer to patients with recent myocardial infarction, arrhythmia, closed-angle glaucoma, prostate disorders. Treatment should be discontinued in the event of severe reactions (mental confusion, urinary retention, cardiac rhythm disorders); • psychic disorders: exacerbation of anxiety, possibility of a suicide attempt at the beginning of therapy, manic episode during treatment.
Correlates of Physical Activity: Why are some People Physically Active and Others Not? Morning Or Evening Activity Improves Neuropsychological Performance and Subjective Sleep Quality in Older Adults kamagra 50 mg otc erectile dysfunction questions. The Person-Oriented Versus the Variable-Oriented Approach: Are they Complementary best kamagra 50 mg erectile dysfunction drugs generic, Opposites discount kamagra 100mg online impotence cure food, Or Exploring Different Worlds? Lifetime Risks for Cardiovascular Disease Mortality by Cardiorespiratory Fitness Levels Measured at Ages 45, 55, and 65 Years in Men. Sleep Restriction Decreases the Physical Activity of Adults at Risk for Type 2 Diabetes. Short and Long Sleep are Positively Associated with Obesity, Diabetes, Hypertension, and Cardiovascular Disease among Adults in the United States. The Pittsburgh Sleep Quality Index: A New Instrument for Psychiatric Practice and Research. Sleep Duration and Mortality: A Prospective Study of 113 138 Middle-Aged and Elderly Chinese Men and Women. Sleep Duration Predicts Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies. Sleep Duration and all- Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies. Association of Leisure Physical Activity and Sleep with Cardiovascular Risk Factors in Postmenopausal Women. Physical Activity, Exercise, and Physical Fitness: Definitions and Distinctions for Health-Related Research. Meta-Analysis of the Relationship between Breaks in Sedentary Behavior and Cardiometabolic Health. Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach. Cross-Sectional Associations of Total Sitting and Leisure Screen Time with Cardiometabolic Risk in Adults. Cross-Sectional Associations between Occupational and Leisure-Time Sitting, Physical Activity and Obesity in Working Adults. The Association between the Framingham Risk Score and Sleep: A Sao Paulo Epidemiological Sleep Study. Validity and Reliability of Measures of Television Viewing Time and Other Non-Occupational Sedentary Behaviour of Adults: A Review. Past Physical Activity, Current Physical Activity, and Risk of Coronary Heart Disease. The Clustering of Health Behaviours in Ireland and their Relationship with Mental Health, Self-Rated Health and Quality of Life. General Cardiovascular Risk Profile for use in Primary Care: The Framingham Heart Study. A Cluster-Analytical Approach Toward Physical Activity and Other Health Related Behaviors. Physical Activity Versus Cardiorespiratory Fitness: Two (Partly) Distinct Components of Cardiovascular Health? Managing Sedentary Behavior to Reduce the Risk of Diabetes and Cardiovascular Disease. Reviewing the Psychometric Properties of Contemporary Circadian Typology Measures. Methods used to Cope with Sleepiness may Perpetuate Sleepiness in College Students with an Evening Type Circadian Preference. Revisiting Lifestyle Risk Index Assessment in a Large Australian Sample: Should Sedentary Behavior and Sleep be Included as Additional Risk Factors? The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part I: Pathophysiology and Clinical Trial Evidence (Risk Factors through Stable Coronary Artery Disease). Healthy Lifestyle Behaviours and Cardiovascular Mortality among Japanese Men and Women: The Japan Collaborative Cohort Study. Associations of Physical Activity, Screen Time with Depression, Anxiety and Sleep Quality among Chinese College Freshmen. Physical Exercise Performed before Bedtime Improves the Sleep Pattern of Healthy Young Good Sleepers. Sleep-Related Disturbances and Physical Inactivity are Independently Associated with Obesity in Adults. Sleep Disturbances and Chronic Disease in Older Adults - Results of the 2003 National Sleep Foundation Sleep in America Survey. Community Prevalence of Ideal Cardiovascular Health, by the American Heart Association Definition, and Relationship with Cardiovascular Disease Incidence. Pre-Diabetes and the Risk for Cardiovascular Disease: A Systematic Review of the Evidence. Epidemiological Evidence for the Links between Sleep, Circadian Rhythms and Metabolism. Associations between Television Viewing Time and overall Sitting Time with the Metabolic Syndrome in Older Men and Women: The Australian Diabetes Obesity and Lifestyle Study. Global, Regional, and National Age–sex Specific all-Cause and Cause-Specific Mortality for 240 Causes of Death, 1990–2013: A Systematic Analysis for the Global Burden of Disease Study 2013. Sustained and Shorter Bouts of Physical Activity are Related to Cardiovascular Health. Problems Associated with Short Sleep: Bridging the Gap between Laboratory and Epidemiological Studies. The Longitudinal Course of Insomnia Symptoms: Inequalities by Sex and Occupational Class among Two Different Age Cohorts Followed for 20 Years in the West of Scotland. The Association of Major Patterns of Physical Activity, Sedentary Behavior and Sleep with Health-Related Quality of Life: A Cohort Study. A Sedentary Day: Effects on Subsequent Sleep and Body Temperatures in Trained Athletes. Comparison of Risk Factors for Fatal Stroke and Ischemic Heart Disease: A Prospective Follow Up of the Health Survey for England. Morningness-Eveningness Interferes with Perceived Health, Physical Activity, Diet and Stress Levels in Working Women: A Cross-Sectional Study. Physical Activity and Public Health: Updated Recommendation for Adults from the American College of Sports Medicine and the American Heart Association. Editorial: Sedentary Behaviour and Biomarkers of Cardiometabolic Health Risk in Adolescents: An Emerging Scientific and Public Health Issue. Accumulation of Lifestyle and Psychosocial Problems and Persistence of Adverse Lifestyle Over Two-Year Follow-Up among Finnish Adolescents. Sedentary Behaviours and Obesity in Adults: The Cardiovascular Risk in Young Finns Study. A Longitudinal Examination of Sleep Quality and Physical Activity in Older Adults.